Mitochondrial bioenergetics
SS-31
Also known as Elamipretide, MTP-131
D-Arg-Dmt-Lys-Phe-NH2 · 991.18 g/mol
A mitochondria-targeting tetrapeptide that concentrates on the inner membrane by binding cardiolipin, widely used as a tool compound in bioenergetics research.
SS-31 carries an alternating aromatic-cationic motif that drives selective accumulation in the inner mitochondrial membrane without requiring a receptor. It binds cardiolipin, and published work associates that interaction with stabilised cristae architecture, better-organised electron-transport supercomplexes, higher ATP output and reduced escape of reactive oxygen species. Notably it is not a conventional free-radical scavenger, which is what makes it a useful mechanistic probe.
Common research areas
- Cardiolipin binding
- Electron transport chain assembly
- Mitochondrial ROS assays
In our catalog
SS-31 10 mg · $60 CAD · ≥99% HPLC
Selected references
- 1. Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential. Int J Mol Sci, 2025. PMID 39940712
- 2. Therapeutic Approaches Involving Mitochondria in the Treatment of Acute Kidney Injury. Semin Nephrol, 2026. PMID 41027799
- 3. Serendipity and the discovery of novel compounds that restore mitochondrial plasticity. Clin Pharmacol Ther, 2014. PMID 25188726
For laboratory research use only. Reference information, not usage guidance or dosing advice.