Pure North Peptides Journal · Compendium
Pinealon: short peptide bioregulator for longevity research
Published 2024-07-22 · Pure North Peptides Editorial · Canada
Short answer. Pinealon is the synthetic tripeptide Glu-Asp-Arg (EDR), one of the Khavinson short-peptide bioregulators studied in pineal-gland and longevity research. Pinealon is not currently stocked by Pure North Peptides, see the current catalog for available reference standards.
Khavinson short peptides
Pinealon belongs to a series of short synthetic peptides developed by V. Khavinson and characterized in published in-vitro and rodent-model research. The class hypothesis is that 3- and 4-residue peptides can cross cellular membranes and engage gene-regulatory networks directly. Mechanism remains an active research question; in-vitro work should pre-specify the assay rather than assume a unified mechanism.
Sequence
L-Glu-L-Asp-L-Arg. Mass 418.40 Da. The very short chain length means the peptide is more soluble and less surface-active than the lipidated peptides on this catalog.
Quality criteria
- RP-HPLC purity ≥ 99% at 220 nm.
- ESI-MS at 418.40 Da ± 0.3 Da.
- Stereochemistry verification (all-L) by chiral HPLC for reference-grade material.
- Net peptide content ≥ 90% (short peptides routinely hit higher AAA values than long chains).
Reconstitution
Highly water-soluble. A 20 mg vial reconstituted with 1.0 mL bacteriostatic water gives a 20 mg/mL stock. Dissolves immediately with no swirling needed. Stable 30 days at 2-8 °C after reconstitution; longer storage as −80 °C aliquots.
Class neighbors
For comparison-pair research, see Epithalon (AEDG, 4-residue). The two are commonly studied as part of the broader short-peptide-bioregulator series. Mass-spec confirmation of identity is more important for short peptides than for long chains because chromatographic separation is harder at low molecular weight, always verify by both HPLC and MS.
Pinealon is not currently part of the Pure North Peptides catalog. For HPLC-verified reference standards shipped across Canada (dispatched within 24-48 hours, ~4 days Canada Post Xpresspost transit), see the current catalog → or review published lab results.
Frequently asked questions
What is Pinealon's sequence?
Glu-Asp-Arg (EDR), an all-L tripeptide. Mass 418.40 Da.
How is Pinealon different from Epithalon?
Pinealon is a tripeptide (3 residues, EDR). Epithalon is a tetrapeptide (4 residues, AEDG). Both belong to the Khavinson short-peptide bioregulator class but engage different research questions.
Is short-peptide identity hard to verify?
Yes, short peptides have less unique chromatographic and mass signatures than long chains. Reference-grade material should show both HPLC purity ≥ 99% and ESI-MS within 0.3 Da.
Storage protocol?
Lyophilized, sealed. After reconstitution 2-8 °C for 30 days or −80 °C aliquots.
Where to source Pinealon in Canada?
Pinealon is not currently stocked by Pure North Peptides. See the current catalog for HPLC-verified reference standards shipped across Canada, dispatched within 24-48 hours (~4 days Canada Post Xpresspost transit).
Disclaimer: All Pure North Peptides products are supplied for laboratory research use only. They are not approved by Health Canada as drugs. See our research-use declaration for full terms.