Pure North Peptides Journal · Compendium
Pinealon: short peptide bioregulator for longevity research
Published 2024-07-22 · Pure North Peptides Editorial · Canada
Short answer. Pinealon is the synthetic tripeptide Glu-Asp-Arg (EDR), one of the Khavinson short-peptide bioregulators studied in pineal-gland and longevity research. Pinealon is not currently stocked by Pure North Peptides — see the current catalog for available reference standards.
Khavinson short peptides
Pinealon belongs to a series of short synthetic peptides developed by V. Khavinson and characterized in published in-vitro and rodent-model research. The class hypothesis is that 3- and 4-residue peptides can cross cellular membranes and engage gene-regulatory networks directly. Mechanism remains an active research question; in-vitro work should pre-specify the assay rather than assume a unified mechanism.
Sequence
L-Glu-L-Asp-L-Arg. Mass 418.40 Da. The very short chain length means the peptide is more soluble and less surface-active than the lipidated peptides on this catalog.
Quality criteria
- RP-HPLC purity ≥ 99% at 220 nm.
- ESI-MS at 418.40 Da ± 0.3 Da.
- Stereochemistry verification (all-L) by chiral HPLC for reference-grade material.
- Net peptide content ≥ 90% (short peptides routinely hit higher AAA values than long chains).
Reconstitution
Highly water-soluble. A 20 mg vial reconstituted with 1.0 mL bacteriostatic water gives a 20 mg/mL stock. Dissolves immediately with no swirling needed. Stable 30 days at 2–8 °C after reconstitution; longer storage as −80 °C aliquots.
Class neighbors
For comparison-pair research, see Epithalon (AEDG, 4-residue). The two are commonly studied as part of the broader short-peptide-bioregulator series. Mass-spec confirmation of identity is more important for short peptides than for long chains because chromatographic separation is harder at low molecular weight — always verify by both HPLC and MS.
Pinealon is not currently part of the Pure North Peptides catalog. For HPLC-verified reference standards shipped across Canada (dispatched within 2 business days, ~4 days Canada Post Xpresspost transit), see the current catalog → or review published lab results.
Frequently asked questions
What is Pinealon's sequence?
Glu-Asp-Arg (EDR), an all-L tripeptide. Mass 418.40 Da.
How is Pinealon different from Epithalon?
Pinealon is a tripeptide (3 residues, EDR). Epithalon is a tetrapeptide (4 residues, AEDG). Both belong to the Khavinson short-peptide bioregulator class but engage different research questions.
Is short-peptide identity hard to verify?
Yes, short peptides have less unique chromatographic and mass signatures than long chains. Reference-grade material should show both HPLC purity ≥ 99% and ESI-MS within 0.3 Da.
Storage protocol?
Lyophilized, sealed. After reconstitution 2–8 °C for 30 days or −80 °C aliquots.
Where to source Pinealon in Canada?
Pinealon is not currently stocked by Pure North Peptides. See the current catalog for HPLC-verified reference standards shipped across Canada, dispatched within 2 business days (~4 days Canada Post Xpresspost transit).
Disclaimer: All Pure North Peptides products are supplied for laboratory research use only. They are not approved by Health Canada as drugs. See our research-use declaration for full terms.