Epithalon: tetrapeptide for telomerase and longevity research
Epithalon (AEDG) is a synthetic tetrapeptide investigated in published telomerase-activity and longevity research. Sequence, mass, and quality criteria.
Short answer. Epithalon is the synthetic tetrapeptide Ala-Glu-Asp-Gly (AEDG), one of the most-studied short-peptide bioregulators in published telomerase-activity and longevity research. It is not currently stocked in the Pure North Peptides catalog, see our current catalog for what we carry.
Sequence
L-Ala-L-Glu-L-Asp-L-Gly. Mass 390.35 Da. Synthesized by standard SPPS with Fmoc protection; final cleavage in TFA. Counter-ion content depends on cleavage cocktail and post-cleavage workup; reference-grade lots should report residual TFA < 1.0%.
Why telomerase research?
The Khavinson group's published in-vitro results show measurable changes in telomerase activity in human cell-line models exposed to AEDG. The mechanism is not settled, direct binding to telomerase has not been demonstrated, and indirect effects via gene-regulatory networks remain hypothesis-stage. Researchers should treat published mechanism claims as hypothesis to test, not as established model.
Quality criteria
- RP-HPLC purity ≥ 99% at 220 nm.
- ESI-MS at 390.35 Da ± 0.3 Da.
- Net peptide content ≥ 90% by AAA (short peptides rarely fall below this).
- Chiral HPLC verification of all-L stereochemistry.
Reconstitution
AEDG is highly water-soluble. 10 mg vial in 1.0 mL bacteriostatic water gives 10 mg/mL stock. Dissolves immediately. Stable 30 days at 2-8 °C; long-term storage as −80 °C single-thaw aliquots.
Comparison-pair research
Pure North publishes laboratory reports for the samples and vial sizes listed in Lab Results. Each report identifies its method, reference, area purity and measured content. Open the matching product page to check coverage for the size you select. A report does not cover every size or future lot; contact customer service if your vial reference differs. Bacteriostatic water has no COA.
Epithalon is not currently in the Pure North Peptides catalog. Email purenorthpeptides@proton.me if you would like to be notified if it is added in the future, or browse the current catalog →
Frequently asked questions
What is Epithalon's sequence?
Ala-Glu-Asp-Gly (AEDG), all-L. Mass 390.35 Da.
Does Epithalon directly bind telomerase?
Direct binding has not been demonstrated in published research as of writing. The mechanism remains hypothesis-stage, gene-regulatory effects are the dominant proposed mode.
How small is Epithalon vs typical research peptides?
Very small, only 4 residues, ~390 Da. For reference, BPC-157 is 15 residues and ~1419 Da, Tirzepatide is 39 residues and ~4813 Da.
Are short peptides harder to verify?
Yes, short peptides have less unique HPLC retention and mass signatures. Both HPLC purity and ESI-MS confirmation are essential on a reference-grade COA.
Where to source Epithalon in Canada?
Epithalon is not currently stocked in the Pure North Peptides catalog. Email purenorthpeptides@proton.me to ask about future availability.
Disclaimer: All Pure North Peptides products are supplied for laboratory research use only. They are not approved by Health Canada as drugs. See our research-use declaration for full terms.
For laboratory research use only. Reference information, not medical advice or human-use guidance.
