Tirzepatide
39-residue dual GIP / GLP-1 receptor agonist, one of the most-studied molecules in metabolic research. Lyophilized, HPLC-verified.
Read about Tirzepatide in the peptide library →The signed certificate for the current Tirzepatidelot isn't published on this page yet. Every lot is tested and the lot-specific COA is available on request — we will not show a certificate that isn't the one in your vial.
Request this lot's signed COA →For laboratory research use only.
Overview
Tirzepatide is a 39-residue synthetic peptide that activates both the GIP and GLP-1 receptors, with a C20 fatty-diacid chain conferring albumin binding and an extended half-life. It is the standard dual-agonist comparator in incretin research and the usual reference point for triple agonists such as retatrutide.
Mechanism
Dual agonist at the GIP and GLP-1 receptors. Published work describes biased signaling at GLP-1R, with weaker beta-arrestin recruitment relative to native GLP-1 and correspondingly reduced receptor internalisation, alongside full GIP-receptor agonism.
Research applications
- GIP and GLP-1 receptor binding and selectivity panels
- cAMP accumulation and beta-arrestin recruitment assays
- Receptor internalisation and biased-signaling studies
- Comparative incretin work against retatrutide and semaglutide
- In-vivo metabolic phenotype models
Reconstitution
Allow vial to reach room temperature before opening (at least 20 minutes). Reconstitute with 1.0 to 2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct the stream onto the lyophilized cake. Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.
Storage & handling
Reconstituted solution is stable for 28 days at 2 to 8 C in the original vial. For longer storage, aliquot into low-binding tubes and hold at -80 C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.
Selected references
- 1. Coskun T et al. LY3298176, a novel dual GIP and GLP-1 receptor agonist. Mol Metab. 2018;18:3-14.
- 2. Willard FS et al. Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist. JCI Insight. 2020;5(17):e140532.
Tirzepatide on PubMed
Independent published literature indexed on PubMed (U.S. National Library of Medicine). Provided for laboratory research reference only.
- PMID 39114288Mechanisms of action and therapeutic applications of GLP-1 and dual GIP/GLP-1 receptor agonistsFront Endocrinol (Lausanne) · 2024 · PubMed →
- PMID 35579691Management of type 2 diabetes with the dual GIP/GLP-1 receptor agonist tirzepatide: a systematic review and meta-analysisDiabetologia · 2022 · PubMed →
- PMID 36050763Tirzepatide, a dual GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes with unmatched effectiveness regrading glycaemic control and body weight reductionCardiovasc Diabetol · 2022 · PubMed →
Tirzepatide questions
- What is Tirzepatide?
- Tirzepatide is a 39-residue synthetic peptide that activates both the GIP and GLP-1 receptors, with a C20 fatty-diacid chain conferring albumin binding and an extended half-life. It is supplied as a lyophilized research reference standard.
- What purity is Tirzepatide, and is there a COA?
- Every lot of Tirzepatide is independently verified by Janoshik (reverse-phase HPLC for purity, mass spec for identity) to a ≥99% purity floor. The lot-specific Certificate of Analysis is tied to the number on the vial label and available on request.
- How is Tirzepatide shipped in Canada?
- Tirzepatide ships domestically across Canada, dispatched within 24-48 hours via Canada Post Xpresspost and arriving in about four days. No border to cross, no customs. Flat $25 CAD shipping, free over $200.
- How do I reconstitute Tirzepatide?
- Allow vial to reach room temperature before opening (at least 20 minutes). Reconstitute with 1.0 to 2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct the stream onto the lyophilized cake. Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.
- How should Tirzepatide be stored?
- Reconstituted solution is stable for 28 days at 2 to 8 C in the original vial. For longer storage, aliquot into low-binding tubes and hold at -80 C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.
- Is Tirzepatide legal to buy in Canada?
- Tirzepatide is sold as a laboratory research reference standard, for laboratory research use only. It is legal to sell for that purpose and is not approved by Health Canada as a drug.
