Ipamorelin
Selective growth-hormone secretagogue (pentapeptide). Favored for minimal reported cortisol/prolactin effect in the literature.
Read about Ipamorelin in the peptide library →The signed certificate for the current Ipamorelinlot isn't published on this page yet. Every lot is tested and the lot-specific COA is available on request — we will not show a certificate that isn't the one in your vial.
Request this lot's signed COA →For laboratory research use only.
Overview
Ipamorelin is a synthetic pentapeptide that selectively activates the growth-hormone secretagogue receptor (GHS-R1a) without measurable activity at receptors associated with cortisol, prolactin, or ACTH release. This selectivity is the experimental signature distinguishing it from earlier secretagogues such as GHRP-2 and GHRP-6. Each vial is lyophilized from acetate buffer, sealed under nitrogen, and shipped ~4 days from our Canadian warehouse.
Mechanism
Selectively activates the growth-hormone secretagogue receptor (GHS-R1a) without measurable activity at receptors associated with cortisol, prolactin, or ACTH release. This selectivity is the experimental signature distinguishing it from earlier secretagogues such as GHRP-2 and GHRP-6.
Research applications
- GHS-R1a binding affinity and selectivity screens
- Pituitary GH-release assays
- Comparative pharmacokinetics versus GHRP-2/GHRP-6 and natural ghrelin
Reconstitution
Allow vial to reach room temperature before opening (at least 20 minutes). Reconstitute with 1.0 to 2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct the stream onto the lyophilized cake. Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.
Storage & handling
Reconstituted solution is stable for 28 days at 2 to 8 C in the original vial. For longer storage, aliquot into low-binding tubes and hold at -80 C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.
Selected references
- 1. Raun K et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552-561.
- 2. Howard AD et al. A receptor in pituitary and hypothalamus that functions in GH release. Science. 1996;273(5277):974-977.
- 3. Smith RG. Development of growth hormone secretagogues. Endocr Rev. 2005;26(3):346-360.
Ipamorelin on PubMed
Independent published literature indexed on PubMed (U.S. National Library of Medicine). Provided for laboratory research reference only.
- PMID 9849822Ipamorelin, the first selective growth hormone secretagogueEur J Endocrinol · 1998 · PubMed →
- PMID 11735244The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formationGrowth Horm IGF Res · 2001 · PubMed →
- PMID 39043357The growth hormone secretagogue receptor 1a agonists, anamorelin and ipamorelinPhysiol Behav · 2024 · PubMed →
Ipamorelin questions
- What is Ipamorelin?
- Ipamorelin is a synthetic pentapeptide that selectively activates the growth-hormone secretagogue receptor (GHS-R1a) without measurable activity at receptors associated with cortisol, prolactin, or ACTH release. It is supplied as a lyophilized research reference standard.
- What purity is Ipamorelin, and is there a COA?
- Every lot of Ipamorelin is independently verified by Janoshik (reverse-phase HPLC for purity, mass spec for identity) to a ≥99% purity floor. The lot-specific Certificate of Analysis is tied to the number on the vial label and available on request.
- How is Ipamorelin shipped in Canada?
- Ipamorelin ships domestically across Canada, dispatched within 24-48 hours via Canada Post Xpresspost and arriving in about four days. No border to cross, no customs. Flat $25 CAD shipping, free over $200.
- How do I reconstitute Ipamorelin?
- Allow vial to reach room temperature before opening (at least 20 minutes). Reconstitute with 1.0 to 2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct the stream onto the lyophilized cake. Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.
- How should Ipamorelin be stored?
- Reconstituted solution is stable for 28 days at 2 to 8 C in the original vial. For longer storage, aliquot into low-binding tubes and hold at -80 C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.
- Is Ipamorelin legal to buy in Canada?
- Ipamorelin is sold as a laboratory research reference standard, for laboratory research use only. It is legal to sell for that purpose and is not approved by Health Canada as a drug.
