Tesamorelin
Stabilized growth-hormone-releasing-hormone analog studied for GH-axis and visceral-adipose research. Lyophilized, HPLC-verified.
Read about Tesamorelin in the peptide library →- Purity (HPLC)
- 99.21%
- Mol. weight
- 5135.86
- Retest by
- 2027-04-24
For laboratory research use only.
Overview
Tesamorelin is a stabilized analog of human growth-hormone-releasing hormone GHRH(1-44), modified with a trans-3-hexenoyl group at the N-terminus to resist dipeptidyl peptidase-4 degradation. It is used as a reference standard in growth-hormone-axis and visceral-adipose research. Lot XR26042502-4 assayed at 99.21% by HPLC.
Mechanism
Binds the GHRH receptor on pituitary somatotrophs and stimulates synthesis and pulsatile release of endogenous growth hormone, with downstream elevation of IGF-1. The N-terminal acylation extends plasma half-life relative to native GHRH(1-44) by blocking DPP-4 cleavage.
Research applications
- GHRH-receptor binding and cAMP accumulation assays
- Pituitary somatotroph secretion models
- GH/IGF-1 axis pharmacodynamic studies
- Visceral adipose tissue and lipolysis research
- DPP-4 stability comparisons against native GHRH
Reconstitution
Allow vial to reach room temperature before opening (at least 20 minutes). Reconstitute with 1.0 to 2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct the stream onto the lyophilized cake. Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.
Storage & handling
Reconstituted solution is stable for 28 days at 2 to 8 C in the original vial. For longer storage, aliquot into low-binding tubes and hold at -80 C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.
Selected references
- 1. Falutz J et al. Metabolic effects of a growth hormone-releasing factor in patients with HIV. N Engl J Med. 2007;357(23):2359-2370.
- 2. Stanley TL et al. Effects of tesamorelin on visceral adipose tissue. JAMA. 2014;312(4):380-389.
Tesamorelin on PubMed
Independent published literature indexed on PubMed (U.S. National Library of Medicine). Provided for laboratory research reference only.
Tesamorelin questions
- What is Tesamorelin?
- Tesamorelin is a stabilized analog of human growth-hormone-releasing hormone GHRH(1-44), modified with a trans-3-hexenoyl group at the N-terminus to resist dipeptidyl peptidase-4 degradation. It is supplied as a lyophilized research reference standard.
- What purity is Tesamorelin, and is there a COA?
- Every lot of Tesamorelin is independently verified by Janoshik (reverse-phase HPLC for purity, mass spec for identity) to a ≥99% purity floor. The lot-specific Certificate of Analysis is tied to the number on the vial label and available on request.
- How is Tesamorelin shipped in Canada?
- Tesamorelin ships domestically across Canada, dispatched within 24-48 hours via Canada Post Xpresspost and arriving in about four days. No border to cross, no customs. Flat $25 CAD shipping, free over $200.
- How do I reconstitute Tesamorelin?
- Allow vial to reach room temperature before opening (at least 20 minutes). Reconstitute with 1.0 to 2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct the stream onto the lyophilized cake. Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.
- How should Tesamorelin be stored?
- Reconstituted solution is stable for 28 days at 2 to 8 C in the original vial. For longer storage, aliquot into low-binding tubes and hold at -80 C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.
- Is Tesamorelin legal to buy in Canada?
- Tesamorelin is sold as a laboratory research reference standard, for laboratory research use only. It is legal to sell for that purpose and is not approved by Health Canada as a drug.
