Neurotrophic signaling
Semax
Also known as ACTH(4-7)-Pro-Gly-Pro
Met-Glu-His-Phe-Pro-Gly-Pro · 813.94 g/mol
A heptapeptide ACTH(4-7) analog with a Pro-Gly-Pro tail for peptidase resistance, studied for BDNF expression and neuroprotection.
Semax takes the ACTH(4-7) fragment and appends Pro-Gly-Pro, which blocks rapid enzymatic degradation while removing the corticotropic activity of the parent hormone. Published work reports elevated BDNF and TrkB receptor expression in hippocampal tissue along with shifts in monoamine turnover. That combination, neurotrophic signaling without steroidogenesis, is why it appears in cognition and cerebral-ischemia literature rather than endocrine studies.
Common research areas
- BDNF / TrkB expression assays
- Neuroplasticity models
- Cerebral ischemia research
In our catalog
Semax 10 mg · $55 CAD · ≥99% HPLC
Related compounds
Selected references
- 1. [Comparison of anticoagulant effects of regulatory proline-containing oligopeptides. Specificity of glyprolines, semax, and selank and potential of their practical application]. Izv Akad Nauk Ser Biol, 2006. PMID 16634437
- 2. Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia. Cell Mol Neurobiol, 2010. PMID 19633950
- 3. Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice. Br J Pharmacol, 2025. PMID 40692165
For laboratory research use only. Reference information, not usage guidance or dosing advice.