Tirzepatide vs Semaglutide: A Canadian Researcher's Comparison
Compare tirzepatide and semaglutide by sequence, receptor profile and laboratory research context, including their key mechanistic differences.
Short answer: Semaglutide is a single GLP-1 receptor agonist; Tirzepatide is a dual GLP-1 / GIP agonist. Both are widely characterized in the metabolic-research literature. Tirzepatide is listed in the catalogue, with its COA temporarily unavailable. Semaglutide is not currently stocked. Another listed reference standard is Retatrutide 20 mg, an HPLC-verified tri-agonist (GLP-1 + GIP + glucagon) supplied for in-vitro research use.
Receptor profile
| Compound | Targets | MW (approx) |
|---|---|---|
| Semaglutide | GLP-1 receptor | ~4113 Da |
| Tirzepatide | GLP-1 + GIP receptors (dual) | ~4814 Da |
What we carry
Retatrutide 20 mg is the GLP-1-class reference standard Pure North currently stocks: an HPLC-verified, lyophilized tri-agonist (GLP-1 + GIP + glucagon) supplied for in-vitro research. Orders are dispatched within 24-48 hours and ship across Canada via Canada Post Xpresspost (~4 days transit).
Tirzepatide and Semaglutide: Not in our catalog. Both are referenced here for academic comparison only. For comparative in-vitro work in this class, Retatrutide 20 mg is the multi-receptor reference standard we stock.
Lyophilization and storage
GLP-1-class reference standards in this family are supplied lyophilized in clear glass vials with chrome-crimped caps, and the lyophilized cake stays stable for 24+ months when stored cold and desiccated. Reconstitute with bacteriostatic water; use within 28 days at 2-8°C.
Choosing for your research
Multi-receptor (tri-agonist) in-vitro comparison → our Retatrutide 20 mg (GLP-1 + GIP + glucagon), the GLP-1-class reference standard we stock. Single-receptor (Semaglutide-class) or dual-receptor (Tirzepatide-class) compounds are not currently in our catalog; browse the full catalog for what is in stock.
Why Pure North Peptides?
Retatrutide is listed in 10 mg and 20 mg sizes, with an independent report for the named 20 mg sample. See the product page and current shipping terms.
Retatrutide 20 mg Browse the catalog
Frequently Asked Questions
How does Tirzepatide differ from Semaglutide pharmacologically?
Tirzepatide is a dual GLP-1/GIP agonist while semaglutide is a single GLP-1 agonist. In published metabolic research models, dual-receptor compounds often show greater effects than single-receptor ones, though direct comparisons depend on dose and protocol. Pure North Peptides does not carry Tirzepatide; this is a literature reference.
Does Pure North Peptides carry Tirzepatide or Semaglutide?
No. Neither is currently stocked; both are referenced here for academic comparison only. Within the GLP-1 class the reference standard we stock is Retatrutide 20 mg (a tri-agonist), supplied for in-vitro research.
How does Pure North Peptides ship across Canada?
Orders are dispatched within 24-48 hours and ship from Canada to all 10 provinces and 3 territories via Canada Post Xpresspost, with roughly 4 days transit for most regions.
Are both compounds the same molecular size?
Tirzepatide is larger (~4814 Da) than semaglutide (~4113 Da) due to the additional GIP-binding domain.
Should I order BAC water with my GLP-1 research peptide?
Yes. Lyophilized peptides require reconstitution with sterile or bacteriostatic water before use. Add a 10 mL vial at purenorthpeptides.com/products/bac-water/.
Disclaimer: All Pure North Peptides products are supplied for laboratory research use only. Refer to our research-use declaration for full terms.
For laboratory research use only. Reference information, not medical advice or human-use guidance.
