Inflammation signaling
KPV
Also known as alpha-MSH(11-13)
Lys-Pro-Val · 342.44 g/mol
The C-terminal tripeptide of alpha-MSH, studied for anti-inflammatory signaling without the pigmentation activity of the parent hormone.
KPV is the three-residue tail of alpha-melanocyte-stimulating hormone. Published work describes it acting intracellularly rather than through surface melanocortin receptors, interfering with NF-kB and MAPK signaling and the cytokine transcription downstream of them. Because it drops the melanocortin-receptor activity of full-length alpha-MSH, it is used in inflammation screens where pigmentation effects would confound the readout.
Common research areas
- NF-kB pathway inhibition assays
- Cytokine expression screens
- Intestinal barrier models
In our catalog
KPV 10 mg · $55 CAD · ≥99% HPLC
Selected references
- 1. Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocr Rev, 2008. PMID 18612139
- 2. Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophore. Adv Exp Med Biol, 2010. PMID 21222263
- 3. New insights into the functions of alpha-MSH and related peptides in the immune system. Ann N Y Acad Sci, 2003. PMID 12851308
For laboratory research use only. Reference information, not usage guidance or dosing advice.