KPV
Tripeptide fragment of α-MSH (Lys-Pro-Val) studied for anti-inflammatory signaling in laboratory models. Lyophilized, HPLC-verified.
Read about KPV in the peptide library →The signed certificate for the current KPVlot isn't published on this page yet. Every lot is tested and the lot-specific COA is available on request — we will not show a certificate that isn't the one in your vial.
Request this lot's signed COA →For laboratory research use only.
Overview
KPV is the C-terminal tripeptide fragment (Lys-Pro-Val) of alpha-melanocyte-stimulating hormone. It carries the anti-inflammatory signaling of the parent hormone without the melanocortin-receptor pigmentation activity, which is why it is widely used as a reference standard in inflammation screens. Supplied lyophilized and sealed under nitrogen.
Mechanism
Tripeptide fragment of alpha-MSH. Reported to act intracellularly rather than through surface melanocortin receptors, with published work describing interference with NF-kB and MAPK pro-inflammatory signaling cascades and downstream cytokine transcription.
Research applications
- NF-kB pathway inhibition assays
- Pro-inflammatory cytokine (TNF-alpha, IL-6) expression screens
- Intestinal epithelial barrier and colitis models
- Comparative studies against full-length alpha-MSH
- Peptide-transporter (PepT1) uptake investigations
Reconstitution
Allow vial to reach room temperature before opening (at least 20 minutes). Reconstitute with 1.0 to 2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct the stream onto the lyophilized cake. Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.
Storage & handling
Reconstituted solution is stable for 28 days at 2 to 8 C in the original vial. For longer storage, aliquot into low-binding tubes and hold at -80 C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.
Selected references
- 1. Dalmasso G et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008;134(1):166-178.
- 2. Brzoska T et al. Alpha-MSH and related tripeptides. Endocr Rev. 2008;29(5):581-602.
KPV on PubMed
Independent published literature indexed on PubMed (U.S. National Library of Medicine). Provided for laboratory research reference only.
- PMID 18612139Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseasesEndocr Rev · 2008 · PubMed →
- PMID 21222263Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophoreAdv Exp Med Biol · 2010 · PubMed →
- PMID 12851308New insights into the functions of alpha-MSH and related peptides in the immune systemAnn N Y Acad Sci · 2003 · PubMed →
KPV questions
- What is KPV?
- KPV is the C-terminal tripeptide fragment (Lys-Pro-Val) of alpha-melanocyte-stimulating hormone. It is supplied as a lyophilized research reference standard.
- What purity is KPV, and is there a COA?
- Every lot of KPV is independently verified by Janoshik (reverse-phase HPLC for purity, mass spec for identity) to a ≥99% purity floor. The lot-specific Certificate of Analysis is tied to the number on the vial label and available on request.
- How is KPV shipped in Canada?
- KPV ships domestically across Canada, dispatched within 24-48 hours via Canada Post Xpresspost and arriving in about four days. No border to cross, no customs. Flat $25 CAD shipping, free over $200.
- How do I reconstitute KPV?
- Allow vial to reach room temperature before opening (at least 20 minutes). Reconstitute with 1.0 to 2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct the stream onto the lyophilized cake. Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.
- How should KPV be stored?
- Reconstituted solution is stable for 28 days at 2 to 8 C in the original vial. For longer storage, aliquot into low-binding tubes and hold at -80 C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.
- Is KPV legal to buy in Canada?
- KPV is sold as a laboratory research reference standard, for laboratory research use only. It is legal to sell for that purpose and is not approved by Health Canada as a drug.
