Coenzyme / cellular energetics
NAD+
Also known as Nicotinamide adenine dinucleotide
C21H27N7O14P2 · 663.42 g/mol
The central redox coenzyme of metabolism and the obligate substrate for sirtuins, PARPs and CD38. A coenzyme, not a peptide.
NAD+ cycles between oxidised and reduced states to carry electrons through glycolysis, the TCA cycle and oxidative phosphorylation. Separately it is consumed as a co-substrate by the sirtuin deacetylases, the PARP DNA-repair enzymes and CD38, which is why intracellular NAD+ availability links mitochondrial function to the DNA-damage response. That dual role, redox carrier and signalling substrate, is the reason it appears across both metabolic and longevity literature.
Common research areas
- Sirtuin activity assays
- PARP / DNA-repair studies
- NAD+/NADH ratio measurement
In our catalog
NAD+ 500 mg · $45 CAD · ≥99% HPLC
Selected references
- 1. NAD⁺ in aging, metabolism, and neurodegeneration. Science, 2015. PMID 26785480
- 2. NAD(+) metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol, 2021. PMID 33353981
- 3. NAD metabolism: Role in senescence regulation and aging. Aging Cell, 2024. PMID 37424179
For laboratory research use only. Reference information, not usage guidance or dosing advice.