In a Canadian research-peptide context, MOTS-c sits within the longevity class of reference standards. This post collects what HPLC-verified labs need to source, store, and reproducibly use this material, sourced from public literature and Pure North's published lot history.
Why MOTS-c matters
MOTS-c is one of the mitochondrial-derived peptides, encoded within the mitochondrial 12S rRNA gene. Since its discovery it has drawn interest for its reported role in AMPK activation and metabolic signaling, which is why it shows up across longevity- and metabolism-focused in-vitro research. For labs sourcing it as a reference standard, the reproducibility gap on most catalogs comes from one place: lots that don't hit ≥ 99% HPLC purity get sold at lower price points instead of being rejected. Pure North's published purity floor is 99.0%, with the average across the catalog at 99.18%. Every lot we ship has a Janoshik-Analytical-verified COA archived publicly at /lab-results/ from synthesis onwards.
The protocol short-version
For Canadian research labs working with MOTS-c, the lifecycle is: on receiving the vial, transfer it immediately to a research-grade −20 °C freezer, reconstitute in sterile bacteriostatic water at the working concentration your protocol specifies, and use within the storage window noted on the lot's COA. Avoid repeated freeze-thaw cycles — every cycle introduces measurable assay drift even on lots that meet the purity floor.
Cross-batch reproducibility
Pure North holds a 5-year retain sample on every lot. If your assay drifts, we run our retain against your in-hand material and pinpoint whether the variance is in the peptide or upstream in your reagent pipeline. This is the most-requested feature labs cite when asked why they reorder.
Where to source it in Canada
Pure North Peptides is Canadian-based and ships across Canada via Canada Post Xpresspost — orders are dispatched within 2 business days, with typical transit around 4 days. Free shipping over $250 CAD; flat $25 below that. MOTS-C is stocked as a reference standard — see MOTS-C 40 mg on the catalog, or browse everything at /products/. Read more on storage and handling in our storage guide, our shipping policy, lot verification at /coa-verify/, or the public lot archive at /lab-results/.